Pulse Nightclub Shooting
The June 2016 shooting spree at the Pulse nightclub in Orlando, Florida, by Omar Mateen—who killed 49 people and wounded 53 more—dwarfed in its lethality all other extremist-related murders in the decade. Mateen, who claimed his attack in the name of ISIS, though there were no known connections between him and that terror organization, achieved the dubious distinction of being the deadliest domestic terrorist since Timothy McVeigh bombed the Murrah Federal Building in Oklahoma City in 1995.